[Morphological peculiarities of the synovial membrane of human knee joint in mature age].

The structural and functional reorganization of the synovial membrane of the knee joint capsule was studied in 22 individuals of mature age (30-65 years) of both genders with the use of light and electron microscopy, histochemistry, immunohistochemistry and morphometry. The morpho-functional peculiarities of the synovial membrane remodeling in the II period of mature age included: increase the in the synovial intima thickness; significant accumulation of type IV collagen at the border of synovial intima with the subintimal fibrovascular layer of synovial membrane; activation of matrix metalloproteinases MMP-2 and MMP-9; increased cell proapoptotic activity in synovial intima. Collectively, these changes may initiate the disturbances in fluid production and the development of the degenerative-dystrophic processes in the articular cartilage at this stage of ontogenesis.

[The effect of cerebrolysin on moderate cognitive impairment in cerebral vascular insufficiency (a clinical and electrophysiological study)].

The efficacy of cerebrolysin has been studied in 40 patients with cerebral vascular insufficiency and moderate cognitive impairment. The treatment in dosage of 10 ml cerebrolysin per 200 ml of physiological solution (20 intravenous injections daily) was effective in this group of patients. The course therapy with cerebrolysin reduced memory and attention disturbances improving the total cognitive status of patients.

[Cerebrolysin treatment of mild cognitive impairment of vascular genesis].

Aim: To evaluate effects of cerebrolysin on cognitive functions in patients with mild cognitive impairment of vascular genesis.

Material And Methods: The examination covered 43 patients aged 40 to 80 years with mild cognitive impairment. We used Tinetti scale for assessment of dynamics in postural disorders; neuropsychological examination was based on Short Scale of Psychic Status Assessment, Mattis Dementia Scale, ADAS- Cog scale, digit test and other tests.

[Morphological characteristics of chronic colitis in workers of gas-processing industry].

Surgical and biopsy material from 76 patients who had been working for a long time at Orenburg gas-processing factory was investigated. Group 1 consisted of 36 workers with classic lymphocytic colitis. Group 2 (40 men) had diarrhea with blood, pains in the abdomen, loss of weight, ulcers at colonoscopy, atypical variants of lymphocytic colitis at colonoscopy.

[A comparative analysis of cognitive disturbances in dementia with Levy's bodies and Alzheimer's disease].

Basing on a neuropsychological study of 50 patients with dementia with Levy's bodies (DLB) and 50 patients with Alzheimer's disease (AD), peculiarities of cognitive impairment in these diseases are discussed. In similar severity of dementia, patients with DLB demonstrated a greater impairment of executive and visual-spatial functions as well as neurodynamic disturbances and patients with AD had more severe memory impairment.