Publications by authors named "E E Gbur"

Article Synopsis
  • siRNA therapeutics have great potential for treating cancer, but effective delivery methods that reduce toxicity while promoting rapid cellular uptake have been difficult to develop.
  • Our team created an innovative siRNA conjugate platform named "siRNA-L," which uses natural albumin in the bloodstream for targeted delivery to tumors without relying on traditional lipid or polymer methods.
  • To enhance the effectiveness of siRNA-L, we synthesized a new conjugate called siRNA-CQ-L that incorporates chloroquine for better endosomal escape and higher gene silencing efficiency, showing no significant toxicity in mice while improving delivery and retention in cancer cells.
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The primary controls for charcoal rot in soybean, caused by the fungal pathogen , are to avoid drought stress and to plant a moderately resistant cultivar. The effects of irrigation and cultivar were determined in 2011 and 2013 at the Lon Mann Cotton Research Station, Marianna, AR. Four soybean cultivars (Hutcheson, Osage, Ozark, and R01581F) were planted in plots with or without added .

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The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics and tumor delivery. Systematic variation of the siRNA conjugate structure reveals that the location of the linker branching site dictates tendency toward albumin association versus self-assembly, while the lipid hydrophobicity and reversibility of albumin binding also contribute to siRNA intracellular delivery.

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Planting date and cultivar maturity group (MG) are major management factors affecting soybean [ (L.) Merr.] yield, but their effect on seed oil and protein concentration, and in particular meal protein concentration, is less understood.

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Background: Diets higher in protein have been reported to improve age-related changes in body composition via increased energy expenditure, shifts in substrate oxidation (SO), and decreased appetite. However, how protein source (e.g.

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