Publications by authors named "E E Del Valle"
Despite all prevention programs, many cases of colorectal cancer (CRC) are diagnosed when they have already metastasized. Herein, chemotherapy is required, and combination of 5-fluorouracil, irinotecan, and leucovorin (FOLFIRI) is one of the first-line treatments chosen. However, it is so toxic that compromises patient outcomes.
View Article and Find Full Text PDFIntroduction: Secondary hyperparathyroidism (sHPT) is a common complication in patients with chronic kidney disease (CKD). Recently, etelcalcetide (EC), an intravenous calcimimetic, has been introduced as a treatment. We evaluated the efficacy of EC in treating sHPT.
View Article and Find Full Text PDFCrude oil toxicity to early life stage fish is commonly attributed to polycyclic aromatic hydrocarbons (PAHs). However, it remains unclear how the polar unresolved complex mixture (UCM), which constitutes the bulk of the water-soluble fraction of crude oil, contributes to crude oil toxicity. Additionally, the role of photomodification-induced toxicity in relation to the polar UCM is not well understood.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the toxic effects of perfluorooctanesulfonamide (PFOSA), a chemical precursor to PFOS, on zebrafish embryos and larvae, focusing on various sub-lethal endpoints.
- PFOSA exposure at 1 µg/L reduced survival slightly compared to controls, while higher doses did not affect hatch rates or induce oxidative stress in older larvae, although activity decreased at 100 µg/L.
- Additionally, PFOSA exposure led to increased transcript levels associated with oxidative stress, apoptosis, and neurotoxicity in larval fish, contributing to understanding PFOSA's potential risks in aquatic ecosystems.
Introduction And Objectives: Microbial translocation contributes to cirrhosis progression and complications. This study aims to investigate whether molecules related to intestinal permeability or microbial translocation can serve as prognostic biomarkers in patients with decompensated cirrhosis.
Materials And Methods: We prospectively evaluated hospitalized patients with decompensated cirrhosis for liver function, complications during hospitalization, in-hospital mortality, composite outcomes of in-hospital mortality and complications, 12-month mortality, and survival rates.