Publications by authors named "E E Bezsonov"
One of the well-known X-linked genetic disorders is hemophilia, which could be hemophilia A as a result of a mutation in the (factor VIII) gene or hemophilia B as a result of a mutation in the (factor IX) gene, leading to insufficient levels of the proteins essential for blood coagulation cascade. In patients with severe hemophilia, factor VIII or factor IX activities in the blood plasma are considerably low, estimated to be less than 1%. This is responsible for spontaneous or post-traumatic bleeding episodes, or both, leading to disease complications and death.
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- - Atherosclerosis is a chronic inflammatory disease characterized by the buildup of fats, cholesterol, and immune cells in arteries, leading to the formation of plaques and is influenced by various vascular and immune cells.
- - The regulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is crucial for vascular health, as their overproduction can trigger inflammatory pathways that contribute to atherosclerosis progression.
- - In contrast, reactive sulfur species (RSS) may protect against atherosclerosis by counteracting the harmful effects of ROS and RNS, and their role in modifying molecules involved in inflammatory signaling is also reviewed.
Atherosclerosis is a chronic inflammatory disease characterized by plaque build-up in the arteries, leading to the obstruction of blood flow. Macrophages are the primary immune cells found in the atherosclerotic lesions and are directly involved in atherosclerosis progression. Macrophages are derived from extravasating blood monocytes.
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