Publications by authors named "E E Benarroch"
Article Synopsis
- The study aimed to identify predicting factors and the frequency of phenoconversion from sporadic adult-onset ataxia (SAOA) to multiple system atrophy (MSA) by reviewing Mayo Clinic patient data from 1998 to 2018.
- Out of 169 ataxia patients, 60 (35.5%) transitioned to MSA, with notable clinical features like early autonomic symptoms, stridor, and dream enactment behavior observed in these patients.
- Imaging and autonomic testing revealed significant differences, such as pontine atrophy and abnormal blood pressure responses, indicating that specific clinical and testing features can help identify individuals likely to phenoconvert to MSA.
Levodopa is the most widely used medication for the symptomatic treatment of Parkinson's disease and, despite being an "old" drug, is still considered the gold standard for offering symptomatic relief. The pharmacokinetic and pharmacodynamics of levodopa have been studied extensively. Our review explores the molecular mechanisms that affect the absorption of this drug, focusing on the large intra- and interindividual variability of absorption that is commonly encountered in daily clinical practice, and on the interaction with other medications.
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