Publications by authors named "E Durot"
Article Synopsis
- * Out of 75 patients with successful BCR expression, a significant majority had mutated immunoglobulin heavy chains (IgVH), and a subgroup of 12 patients showed a highly dominant BCR clone associated with worse clinical outcomes.
- * The results indicated that high clonal dominance correlates with reduced BCR diversity and increased expression of specific genes, leading to poorer progression-free survival (PFS) and overall survival (OS) rates, corroborated by an independent patient cohort analysis.
JCO Primary analysis of the phase III randomized AATT study showed that younger patients with peripheral T-cell lymphoma (PTCL) consolidated with autologous or allogeneic transplantation (alloSCT) had similar event-free survival (EFS) and overall survival (OS). Seven-year EFS of patients randomly assigned to alloSCT was 38% (95% CI, 25 to 52) compared with 34% (95% CI, 22 to 47) for patients randomly assigned to autologous transplantation of hematopoietic stem cells (autoSCT); OS was 55% (95% CI, 41 to 69) and 61% (95% CI, 47 to 74). Among patients undergoing alloSCT (n = 26) or autoSCT (n = 41) on study, the cumulative progression/relapse rate was 8% (95% CI, 0 to 19) and 55% (95% CI, 35 to 74).
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- The study investigates the role of the cerebellum-to-liver uptake ratio (CLIP) as a prognostic factor for patients with post-transplant lymphoproliferative disorders (PTLD), in addition to the International Prognostic Index (IPI) score.
- A total of 97 PTLD patients were analyzed, revealing that both a higher IPI score (≥ 3) and lower CLIP (< 3.24) correlated with poorer progression-free survival (PFS) outcomes.
- While CLIP shows potential as a predictor for PFS, its association with overall survival (OS) was not statistically significant, indicating that further research is needed to validate these findings.