Publications by authors named "E Drost"
Article Synopsis
- Bacterial meningitis can lead to severe complications, including a rare condition called noncompressive myelopathy, which affects spinal cord function.
- In a study of over 3,000 adults with bacterial meningitis, noncompressive myelopathy was identified in seven cases, with patients experiencing leg or arm and leg weakness after an average of nine days post-admission.
- While some improvement in spinal function was noted during hospitalization, all patients exhibited lasting neurological deficits, indicating that while the condition is uncommon, it remains a serious outcome of bacterial meningitis.
Background: Patients with bacterial meningitis can be severely ill necessitating intensive care unit (ICU) treatment. Here, we describe clinical features and prognostic factors of adults with bacterial meningitis admitted to the ICU in a nationwide prospective cohort study.
Methods: We prospectively assessed clinical features and outcome of adults (age > 16 years) with community-acquired bacterial meningitis included in the MeninGene study between March 1, 2006 and July 1, 2022, that were initially admitted to the ICU.
Meningeal inflammation strongly associates with demyelination and neuronal loss in the underlying cortex of progressive MS patients, thereby contributing significantly to clinical disability. However, the pathological mechanisms of meningeal inflammation-induced cortical pathology are still largely elusive. By extensive analysis of cortical microglia in post-mortem progressive MS tissue, we identified cortical areas with two MS-specific microglial populations, termed MS1 and MS2 cortex.
View Article and Find Full Text PDFTropical cyclones generate extreme waves that can damage coral reef communities. Recovery typically requires up to a decade, driving the trajectory of coral community structure. Coral reefs have evolved over millennia with cyclones.
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