Publications by authors named "E Drew Toomer"
Article Synopsis
- * A study utilizing quantitative proteomics and PLK1 inhibition uncovered how extensively PLK1 influences protein breakdown at this stage of the cell cycle, validating numerous regulated proteins.
- * One important finding is that the degradation of A-kinase anchor protein 2 (AKAP2) through PLK1 impacts cytoskeletal organization during mitosis, revealing PLK1's significant role in shaping the proteins involved in cell division, which may relate to cancer when PLK1 levels are increased.
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCF. However, the magnitude to which PLK1 shapes the mitotic proteome has not been characterized.
View Article and Find Full Text PDFBackground: While coverage of long-lasting insecticide-treated nets (LLIN) has steadily increased, a growing number of studies report gaps between net ownership and use. We conducted a mixed-methods social science study assessing the importance of net preference and use after Olyset® LLINs were distributed through a mass campaign in rural communities surrounding Iquitos, the capital city of the Amazonian region of Peru.
Methods: The study was conducted in the catchment area of the Paujil and Cahuide Health Centres (San Juan district) between July 2007 and November 2008.
Background: Victims of Buruli ulcer disease (BUD) frequently report to specialized units at a late stage of the disease. This delay has been associated with local beliefs and a preference for traditional healing linked to a reportedly mystical origin of the disease. We assessed the role beliefs play in determining BUD sufferers' choice between traditional and biomedical treatments.
View Article and Find Full Text PDFBackground: While IPTp-SP is currently being scaled up in sub-Saharan Africa (SSA), the coverage with the required>or=2 doses of SP remains considerably short of the Roll Back Malaria (RBM) goal of 80%, not to mention of the recently advocated universal coverage.
Methods: The study triangulates quantitative data from a health center randomized community-based trial on IPTp-SP effectiveness and the additional benefit of a promotional campaign with qualitative data from focused ethnography.
Findings: In rural Burkina Faso, despite the significantly higher risk of malaria infection among adolescent primigravidae (PG) (OR 2.