Publications by authors named "E Drazanova"
Myocardial remodelling involves structural and functional changes in the heart, potentially leading to heart failure. The deoxycorticosterone acetate (DOCA)/salt model is a widely used experimental approach to study hypertension-induced cardiac remodelling. It allows to investigate the mechanisms underlying myocardial fibrosis and hypertrophy, which are key contributors to impaired cardiac function.
View Article and Find Full Text PDFBackground: Major depressive disorder (MDD) is a mental illness with a high worldwide prevalence and suboptimal pharmacological treatment, which necessitates the development of novel, more efficacious MDD medication. Nuclear magnetic resonance (NMR) can non-invasively provide insight into the neurochemical state of the brain using proton magnetic resonance spectroscopy (H MRS), and an assessment of regional cerebral blood flow (rCBF) by perfusion imaging. These methods may provide valuable in vivo markers of the pathological processes underlying MDD.
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- Antipsychotic medications, while essential for treating severe mental illnesses, often lead to metabolic side effects like weight gain and diabetes, presenting challenges in managing these complications.
- A study using female rats examined the effects of the antipsychotic olanzapine alongside the GLP-1 receptor agonist dulaglutide, revealing that while dulaglutide modestly reduced food intake, it did not reverse olanzapine's harmful serum lipid changes on its own.
- However, combining dulaglutide with food restriction resulted in significant weight loss and improved metabolic markers, suggesting that integrating lifestyle changes with GLP-1 RA treatment may offer better therapeutic outcomes.
Purpose: The aim of this study is to design a method of myocardial T1 quantification in small laboratory animals and to investigate the effects of spatiotemporal regularization and the needed acquisition duration.
Methods: We propose a compressed-sensing approach to T1 quantification based on self-gated inversion-recovery radial two/three-dimensional (2D/3D) golden-angle stack-of-stars acquisition with image reconstruction performed using total-variation spatiotemporal regularization. The method was tested on a phantom and on a healthy rat, as well as on rats in a small myocardium-remodeling study.
Gross pathology inspection (patho) is the gold standard for the morphological evaluation of focal myocardial pathology. Examination with 9.4 T magnetic resonance imaging (MRI) is a new method for very accurate display of myocardial pathology.
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