Publications by authors named "E Doran"
Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer's disease (AD). Here, we compare the frontal cortex proteome of people with Down syndrome-Alzheimer's disease (DSAD) to demographically matched cases of early-onset AD and healthy ageing controls. We find wide dysregulation of the proteome, beyond proteins encoded by chromosome 21, including an increase in the abundance of the key AD-associated protein, APOE, in people with DSAD compared to matched cases of AD.
View Article and Find Full Text PDFObjective: The objective of this study is to systematically review the clinical studies investigating the use of steroids in adult epilepsy.
Methods: This systematic review utilized Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) to examine literature on the use of steroids in adult epilepsy. Three databases, Embase, PubMed and Medline, were searched and clinical studies fitting the inclusion and exclusion criteria were included for review.
Introduction: Aging adults with Down syndrome (DS) accumulate Alzheimer's disease (AD) neuropathology, including amyloid beta plaques and neurofibrillary tangles, by age 40.
Methods: We present findings from an individual with DS who remained cognitively stable despite AD neuropathology. Clinical assessments, fluid biomarkers, neuroimaging, and neuropathological examinations were conducted to characterize her condition.
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable factors, with its molecular etiology still unclear. Here we present a spatial transcriptomic (ST) and single-nucleus transcriptomic survey of late-onset sporadic AD and AD in Down syndrome (DSAD). Studying DSAD provides an opportunity to enhance our understanding of the AD transcriptome, potentially bridging the gap between genetic mouse models and sporadic AD.
View Article and Find Full Text PDFComparing research attitudes in Down syndrome and non-Down syndrome research decision-makers.
Alzheimers Dement (N Y)
July 2024
Article Synopsis
- The study investigates recruitment challenges faced by decision-makers for individuals with and without Down syndrome (DS), emphasizing the need to understand differing research attitudes to avoid sample bias.* ! -
- Using data from two registries, the study compares Research Attitudes Questionnaire (RAQ) scores between non-DS decision-makers and family decision-makers of individuals with DS.* ! -
- Although overall RAQ scores were similar, the study found that DS decision-makers expressed a greater sense of responsibility to help others but were less optimistic about medical research curing major diseases in their lifetime.* !