Publications by authors named "E Dondi"
In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. β-Catenin is a multifunctional protein that stabilizes cell-cell interactions and regulates cell survival through its transcriptional activity. We used chronic lymphocytic leukemia (CLL) cells as a cellular model to study the role of β-catenin in regulating the adhesion of tumor cells to their microenvironment, which is necessary for tumor cell survival and accumulation.
View Article and Find Full Text PDFTyrosine kinase inhibitors: the role of pharmacokinetics and pharmacogenetics.
Expert Opin Drug Metab Toxicol
November 2023
Article Synopsis
- Tyrosine kinase inhibitors block specific kinases that disrupt signaling pathways in tumor cells, and this study focused on their effects in chronic myeloid leukemia patients, particularly looking at age and sex differences.
- Most patients were pediatric boys treated primarily with imatinib and dasatinib, and while 82.4% of the participants were male, no significant pharmacokinetic differences based on sex were observed.
- An inverse relationship was found between age and imatinib plasma concentration, and lower dasatinib levels in plasma compared to cerebrospinal fluid were noted, highlighting the importance of therapeutic drug monitoring to optimize treatment plans based on individual drug levels.