Publications by authors named "E Donaldson"
Background: PAXLOVID consists of nirmatrelvir, an inhibitor of SARS-CoV-2 main protease (Mpro), copackaged with ritonavir, a pharmacokinetic enhancer. Nirmatrelvir/ritonavir received emergency use authorization in the United States in 2021 and was approved in 2023. However, there is limited published information on SARS-CoV-2 clinical resistance to nirmatrelvir/ritonavir.
View Article and Find Full Text PDFPurpose Of Review: As injectable cabotegravir for pre-exposure prophylaxis (CAB PrEP) is introduced in sub-Saharan Africa, it is important to understand how behavioral drivers may influence women's decisions around whether or not to use it.
Recent Findings: Facilitating factors include prior familiarity with injections and the perceived efficacy of CAB PrEP, while barriers include a fear or dislike of needles and negative attitudes held by community members and influencers. Further research is needed to fully understand behavioral factors affecting African women's CAB PrEP use.
Article Synopsis
- Verrucous carcinoma (VC) is a slow-growing, low-grade skin cancer that typically appears wart-like and commonly affects the oral cavity, anogenital region, and plantar surfaces, leading to diagnostic challenges due to its benign appearance.
- This study reports on six cases of plantar VC excised between 2014-2023, all of whom experienced recurrence despite initially negative margins.
- The findings suggest that aggressive surgical intervention is necessary for effective management of plantar VC, as repeated operations often lead to eventual amputation due to recurring lesions.
Article Synopsis
- The report showcases the largest case series on frostbite injuries that needed microsurgical reconstruction for preserving limbs, highlighting that conservative management is often insufficient in severe cases.
- A retrospective review from 2008 to 2022 was conducted on eight patients who underwent free tissue transfer, documenting demographics, surgical details, and outcomes.
- Results showed all 16 surgical flaps survived, with a mean follow-up of 505.7 days, and all patients eventually regained the ability to bear weight on their lower extremities within about 125 days after their injuries.
Synovial lipomatosis is a rare condition characterized by adipocyte proliferation within joint synovial tissue. It most commonly affects the knee and is typically intra-articular. Only 5 published case reports describe extra-articular synovial lipomatosis of the wrist.
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