Publications by authors named "E Dominguez"
Perioperative pain control in open cranial vault reconstruction (CVR) poses significant challenges. Narcotic use may confound signs of neurological deterioration and cause medication-induced complications. Previous studies have shown improved health outcomes in CVR with reduced narcotic use.
View Article and Find Full Text PDFThe anti-apoptotic protein myeloid cell leukemia-1 (Mcl-1) contributes to the pathophysiology of acute myeloid leukemia (AML) and certain B-cell malignancies. Tumor dependence on Mcl-1 is associated with resistance to venetoclax. Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models.
View Article and Find Full Text PDFArticle Synopsis
- TFAP2C is a crucial transcription factor in the development of trophoblast cells and hemochorial placentation, particularly in rats, which have a placentation process similar to humans.
- Research using genome editing showed that completely removing TFAP2C led to prenatal death, while reducing its levels resulted in less invasion of trophoblast cells into the uterus.
- Conditional mutagenesis revealed that targeted disruption of TFAP2C in invasive trophoblast cells hindered their invasion capacity and affected growth, indicating its important role in both early and later stages of placental development.
Transcription factor AP-2 gamma ( ) has been identified as a key regulator of the trophoblast cell lineage and hemochorial placentation. The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which resembles human placentation. expressed in multiple trophoblast cell lineages, including invasive trophoblast cells situated within the uterine-placental interface of the rat placentation site.
View Article and Find Full Text PDFImpact of universal use of the McGrath videolaryngoscope as the first option for all intubations in the operating room: The multicentre prospective before-after VIDEOLAR-SURGERY study protocol.
Rev Esp Anestesiol Reanim (Engl Ed)
November 2024
Article Synopsis
- The study aims to determine if the McGrath video laryngoscope, used as the first option for tracheal intubation, improves ease of intubation and reduces complications compared to the traditional Macintosh laryngoscope.
- It's conducted as a multicenter trial involving 35 anesthesiologists across several hospitals, tracking outcomes before and after implementation of the video laryngoscope.
- The study has ethical approval, requires informed consent from participants, and intends to publish its findings in a peer-reviewed journal and present at scientific conferences.