Publications by authors named "E Doche"
Article Synopsis
- This study investigates the effectiveness of intravenous thrombolysis (IVT) in treating large-vessel occlusion strokes, particularly focusing on how thrombus composition affects its success in patients receiving mechanical thrombectomy.
- Researchers analyzed the thrombi from 104 stroke patients, using advanced mass spectrometry and liquid chromatography to assess factors influencing fibrin content and fibrinolytic activity (FA).
- Results showed that fibrin-rich thrombi responded better to the recombinant tissue-type plasminogen activator (r-tPA) treatment, while the presence of erythrocytes and neutrophils negatively impacted FA, indicating the complexity of thrombus structure in treatment outcomes.
Neuroprotective effects of lactate and ketone bodies in acute brain injury.
J Cereb Blood Flow Metab
July 2024
The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage.
View Article and Find Full Text PDFIntroduction: Patients with chronic kidney disease (CKD) have an increased risk of stroke, and CKD seems associated with worse outcome after a stroke. The main objective of our study RISOTTO was to evaluate the influence of CKD and acute kidney injury (AKI) on the clinical outcome and mortality of ischemic stroke patients after thrombolysis and/or thrombectomy.
Methods: This multicenter cohort study included patients in the acute phase of ischemic stroke due to large artery occlusion managed by thrombectomy.
Background: Carotid free-floating thrombus (CFFT) is an uncommon disorder. The aim of this study was to describe a French cohort of CFFT patients.
Methods: We conducted a retrospective monocentric study from a Stroke Center among patients admitted for stroke with CFFT.
Purpose: Ketogenic diet (KD) is recommended to avoid intense [F]FDG myocardial physiologic uptake in PET imaging. Neuroprotective and anti-seizure effects of KD have been suggested, but their mechanisms remain to be elucidated. This [F]FDG PET study aims to evaluate the effect of KD on glucose brain metabolism.
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