Publications by authors named "E Del Bono"
Article Synopsis
- - Omalizumab is an effective treatment for chronic spontaneous urticaria (CSU) resistant to antihistamines, but around 10% of patients do not respond to it; this study evaluated its effectiveness and safety over 8 years in 296 patients.
- - Among the patients, 40.4% were early responders, while 8.6% were non-responders; factors like having no inducible urticaria and higher IgE levels were linked to better responses.
- - The study found that omalizumab had a long-term drug survival rate of 53.5%, with most discontinuations related to clinical remission rather than ineffectiveness, indicating that it is generally safe and effective over time
Reversing CD8 T cell dysfunction is crucial in treating chronic hepatitis B virus (HBV) infection, yet specific molecular targets remain unclear. Our study analyzed co-signaling receptors during hepatocellular priming and traced the trajectory and fate of dysfunctional HBV-specific CD8 T cells. Early on, these cells upregulate PD-1, CTLA-4, LAG-3, OX40, 4-1BB, and ICOS.
View Article and Find Full Text PDFBackground & Aims: Liver diseases resulting from chronic HBV infection are a significant cause of morbidity and mortality. Vaccines that elicit T-cell responses capable of controlling the virus represent a treatment strategy with potential for long-term effects. Here, we evaluated vaccines that induce the activity of type I natural killer T (NKT) cells to limit viral replication and license stimulation of conventional antiviral T-cells.
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