Carob is not allergenic in peanut-allergic subjects.

Background: The antigenic potential of proteins from the carob bean, a member of the legume family used as a food additive, have not so far been investigated and legumes share antigenic proteins with peanut, a potent trigger of anaphylaxis.

Objective: To assess the carob protein determinants of sensitization in peanut-allergic children.

Methods: In a prospective, double-blind, placebo-controlled study 12 patients (median age 9.

Effect of nedocromil sodium on aspecific bronchial hyper-reactivity in asthmatic children.

The purpose of this study was to evaluate whether nedocromil sodium benefits urban asthmatic children showing seasonal bronchial hyper-reactivity to ultrasonic nebulization of distilled water (UNDW). A prospective, randomized, placebo-controlled, parallel-group, double-blind study was carried out at the outpatient pulmonology service at a tertiary-care teaching hospital. Twelve children living in Milan, who were 7-17 years of age, who were SPT and RAST-negative to perennial allergens, who were suffering from episodic asthma, and showing seasonal bronchial hyper-reactivity to UNDW during winter, participated in this study.