Publications by authors named "E De Luca"
Wearable technology has advanced significantly, offering real-time monitoring of athletes' physiological parameters and optimizing training and recovery strategies. Recent developments focus on biosensor devices capable of monitoring biochemical parameters in addition to physiological ones. These devices employ noninvasive methods such as sweat analysis, which reveals critical biomarkers like glucose, lactate, electrolytes, pH, and cortisol.
View Article and Find Full Text PDFGrafting has been exploited since 7000 BC to enhance productivity, disease resistance, and adaptability of cultivated plants to stressful conditions especially in woody crops such as grapevine (Vitis spp.). In contrast, the application of sequence specific double-stranded RNAs (dsRNAs) to control fungal pathogens and insect pests has only been recently developed.
View Article and Find Full Text PDFWe report an important role for microglia in regulating neuroplasticity within phrenic motor neurons. Brief episodes of low oxygen (acute intermittent hypoxia; AIH) elicit a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF) that is regulated by the balance of competing serotonin vs adenosine-initiated cellular mechanisms. Serotonin arises from brainstem raphe neurons, but the source of adenosine is unknown.
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- Cisplatin-induced ototoxicity (CIO) leads to irreversible hearing loss and is influenced by both clinical factors and genetic variants, with polygenic scores (PGS) emerging as a potential predictive tool for identifying individuals at risk for CIO.
- * Researchers developed two PGSs based on large-scale hearing loss GWAS data and RNA sequencing from murine inner ear cells affected by cisplatin, revealing that one PGS significantly outperformed the other in predicting CIO risk.
- * This study presents the first PGS for CIO and suggests that combining genetic data with biological insights can enhance pharmacogenomic research, ultimately aiding in personalized treatment plans for patients undergoing cisplatin therapy.
Background: Despite advancements in psoriasis treatment, a gap remains in aligning patient satisfaction with clinical outcomes. Our study aimed to evaluate which clinical and psychological factors may impact treatment satisfaction in psoriatic patients undergoing long-term biological therapies.
Methods: We performed an observational, cross-sectional, single-center study involving adult patients with moderate-to-severe psoriasis treated with biologics for at least 12 months.