Publications by authors named "E De Garate"
Congenital heart defects (CHD) introduce haemodynamic changes; e.g., bicuspid aortic valve (BAV) presents a turbulent helical flow, which activates aortic pathological processes.
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- This research looked at how reliable two different computer programs are at measuring a heart problem called mitral regurgitation (MR) using special heart scans.
- They used data from 35 patients and tested different ways to measure MR.
- The study found that both computer programs worked really well together, showing that the new 4D-flow method is just as good as the older methods for measuring MR.
Article Synopsis
- The study investigates how bicuspid aortic valve (BAV) leads to dilation of the ascending aorta (AAo) and seeks to understand the molecular and structural changes involved in this condition.
- Researchers analyzed aortic tissue from BAV patients with aortopathy, focusing on differences between dilated and non-dilated segments, specifically looking at microRNAs, protein content, and elastic fiber degeneration.
- The findings revealed five differentially expressed microRNAs linked to dysregulated genes involved in key signaling pathways, alongside structural changes such as reduced elastic fibers in dilated aortic segments with increased wall shear stress.
Background: A substantial number of patients present with a suspected ACS and non-obstructive coronary arteries; sex differences in these patients are not well understood. This study aims to evaluate the impact of sex on clinical presentation and outcome in patients with suspected acute coronary syndrome (ACS) and non-obstructive coronary arteries with a final diagnosis confirmed by cardiovascular magnetic resonance imaging (CMR).
Methods: Consecutive patients with ACS and non-obstructive coronary arteries (n = 719) with an unclear cause from a single tertiary centre who were referred for CMR were included.