Aortic valve repair in a middle-income country: Exceptional outcomes and mid-term results.

Objective: Aortic valve repair has proven to be a low-risk perioperative procedure, with favorable mid-term outcomes and additional benefits linked to the avoidance of prosthetic valves, including freedom from anticoagulation and reintervention, reduced risk of endocarditis, and thromboembolic complications. Furthermore, an aortic valve repair program in Colombia confers potential advantages specific to our population, considering the sociodemographic factors of middle-income countries.

Methods: A retrospective analysis was conducted on the clinical and perioperative results, as well as mid-term follow-up data of patients who underwent aortic valve repair surgery at 2 Colombian health institutions between March 2018 and December 2023.

The role of radium-223 in the evolving treatment landscape of metastatic castration-resistant prostate cancer: a narrative review.

The treatment of metastatic castration-resistant prostate cancer (mCRPC) has been rapidly evolving over the last two decades. The advent of new androgen receptor pathway inhibitors (ARPIs) such as abiraterone acetate or enzalutamide marks a great advance for treating mCRPC patientd in the pre- and post-docetaxel settings. The subsequent approval of ARPIs in early stages-i.

Comprehensive evaluation of volatile compounds and sensory profiles of coffee throughout the roasting process.

Roasting is a crucial process that induces chemical and sensory transformations in coffee beans. Although research indicates that roasting alters the volatile composition of coffee, most studies have collected samples at spaced intervals. Therefore, a continuous and comprehensive evaluation of the commercial roasting process is lacking.

Matching-adjusted indirect comparison of talazoparib plus enzalutamide versus abiraterone acetate and docetaxel in mCRPC.

Aims: The absence of direct comparisons between talazoparib plus enzalutamide (TALA+ENZA) and current standard of care hinders evaluating their relative efficacy for first-line (1 L) metastatic castration resistant prostate cancer (mCRPC). This study aimed to compare TALA+ENZA (TALAPRO-2) to abiraterone acetate plus prednisone (AAP) (COU-AA-302) and docetaxel (TAX 327) using a matching-adjusted indirect treatment comparison (MAIC).

Methods: A systematic literature review using the Ovid® interface was performed to identify relevant evidence.

Uncovering the Techno-Economic and Environmental Implications of a Multiproduct Biorefinery from Exhausted Olive Pomace.

Biorefineries are pivotal in advancing sustainability, yet most studies remain confined to laboratory scales, lacking comprehensive industrial-level analyses. In this work, the laboratory experiments are scaled up to design and assess the techno-economic and environmental implications of a multiproduct biorefinery system producing antioxidant extracts, lignin, and bioethanol from exhausted olive pomace, a residual biomass from olive oil extraction. Using process simulation and life cycle assessment, five scenarios were evaluated, varying in electricity sources (national mix, solar, wind, or olive biomass) and the heat and cooling sources (fossil natural gas or synthetic natural gas from capture CO and electrolytic hydrogen), with one scenario incorporating a carbon capture and storage (CCS) system.