[Management of patients developing acute gastro-intestinal graft-versus-host-disease: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic cell transplantation (allo-HCT) with a frequency range of 30% to 50%. GVH is the leading cause of non-relapse-related deaths and a cause early mortality. Gastro-intestinal (GI) GVH results in digestive manifestations that involve the small intestine and the colon.

N-Heterocyclic Olefin-Ligated Palladium(II) Complexes as Pre-Catalysts for Buchwald-Hartwig Aminations.

New N-heterocyclic olefins (NHOs) are described with functionalization on the ligand heterocyclic backbone and terminal alkylidene positions. Various Pd -NHO complexes have been formed and their use as pre-catalysts in Buchwald-Hartwig aminations was explored. The most active system for catalytic C-N bond formation between hindered arylamine and arylhalide substrates was accessed by combining a backbone methylated NHO with [Pd(cinnamyl)Cl] in the presence of NaOtBu as a base.

Lake Tauca highstand (Heinrich Stadial 1a) driven by a southward shift of the Bolivian High.

Heinrich events are characterized by worldwide climate modifications. Over the Altiplano endorheic basin (high tropical Andes), the second half of Heinrich Stadial 1 (HS1a) was coeval with the highstand of the giant paleolake Tauca. However, the atmospheric mechanisms underlying this wet event are still unknown at the regional to global scale.

The endoscopy patient with a history of sexual abuse: strategies for compassionate care.

Incident estimates of sexual abuse in children and adults in the United States range from 6% to 74%, depending on case findings and documentation methods. A past history of abuse can put the patient at risk of developing physical and psychological sequelae including fear of medical procedures. Invasive procedures such as endoscopy and colonoscopy may further exacerbate fears and provoke stress reactions in patients with a past history of abuse.

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.

Angiopoietin-2 (Ang2) exhibits broad expression in the remodeling vasculature of human tumors but very limited expression in normal tissues, making it an attractive candidate target for antiangiogenic cancer therapy. To investigate the functional consequences of blocking Ang2 activity, we generated antibodies and peptide-Fc fusion proteins that potently and selectively neutralize the interaction between Ang2 and its receptor, Tie2. Systemic treatment of tumor-bearing mice with these Ang2-blocking agents resulted in tumor stasis, followed by elimination of all measurable tumor in a subset of animals.