Publications by authors named "E Dale Everett"
Article Synopsis
- This study investigates the effects of excessive fluoride on the microstructure of dentine in mice, as previous research has mostly focused on its impact on enamel.* -
- Male C57BL6/J mice were divided into four groups, receiving different fluoride concentrations in their drinking water for six weeks, after which various analyses were conducted to evaluate enamel and dentine properties.* -
- Results indicated that high fluoride exposure (50-125 ppm) led to enamel hypoplasia, reduced dentine mineral density, and changes in the structure of the dentine-pulp complex, demonstrating significant negative effects of excessive fluoride consumption.*
Article Synopsis
- - Fluoride ingestion during tooth development can lead to dental fluorosis, and it activates histone acetyltransferase (HAT), which modifies the protein p53 and contributes to fluoride toxicity in specific mouse cells (LS8).
- - The study showed that fluoride modifies histone acetylation, altering gene expression in LS8 cells, as evidenced by increased acetylation levels of certain genes and corresponding mRNA expression when treated with fluoride.
- - This research is the first to highlight that fluoride treatment can lead to epigenetic changes through H3 acetylation, indicating a need for further investigation into how fluoride affects enamel development on a genetic level.
Purpose Of Review: Despite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of associated adverse effects, including dependence and overdose, as demonstrated throughout the current opioid crisis. This is likely related to a failure in proving the efficacy of alternative analgesics in clinical trials, despite strong evidence supporting the potential for effective analgesia through in vitro studies. While NaV1.
View Article and Find Full Text PDFThe care of a patient with neurologic disease at end-of-life requires expertise in addressing advance care planning, hospice, symptom management, and caregiver support. Neurologists caring for patients with advanced neurologic disease often identify changes in disease trajectory, functional status, or goals of care that prompt discussions of advance care planning and hospice. Patients nearing end-of-life may develop symptoms such as dyspnea, secretions, delirium, pain, and seizures.
View Article and Find Full Text PDFRAD51 complex plays an important role in homologous recombination deficiency and germline mutations have a well-documented association with breast and tubo-ovarian carcinoma, as well as serous-type endometrial carcinoma. We report a family of French Canadian ancestry with a germline mutation in RAD51D and two sisters presenting with endometrial carcinoma, endometrioid-type. The risk factors for endometrial adenocarcinoma, endometrioid-type are discussed in the context of the RAD51-associated carcinomas described to date.
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