Publications by authors named "E Dafnis"
Introduction: Management of the Primary Membranous Nephropathy (PMN) usually involves administration of immunosuppressives. Cyclophosphamide (Cyclo) and Calcineurin Inhibitors (CNIs) are both widely used but only limited data exist to compare their efficacy in long term follow-up.
Aim: The aim of the present study was to estimate and compare long term effects of Cyclo and CNIs in patients with PMN.
Article Synopsis
- The study looked at how to diagnose and treat a kidney disease called primary membranous nephropathy (PMN) by examining specific features in kidney samples.
- Researchers analyzed the samples from 752 patients to see how conditions like focal segmental sclerosis (FSGS) and tubular atrophy (TA) affected kidney health.
- They found that certain conditions in the kidneys could predict how well they would function and help decide if patients needed special immune-suppressing treatments.
Rationale & Objective: Lecithin-cholesterol acyltransferase (LCAT) catalyzes the maturation of high-density lipoprotein. Homozygosity for loss-of-function mutations causes familial LCAT deficiency (FLD), characterized by corneal opacities, anemia, and renal involvement. This study sought to characterize kidney biopsy findings and clinical outcomes in a family with FLD.
View Article and Find Full Text PDFWe have investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of HDL. Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.
View Article and Find Full Text PDFBackground: Chronic Kidney Disease (CKD) is a relatively common condition not only associated with increased morbidity and mortality but also fuelling End Stage Renal Disease (ESRD). Among developed nations, Greece has one of the highest ESRD incidence rates, yet there is limited understanding of the epidemiology of earlier stages of CKD.
Methods: Cross-sectional survey of pre-dialysis CKD outpatients in nephrology clinics in the National Health Care system between October 2009 and October 2010.