Publications by authors named "E Dacosto"
Purpose: Lateral sleep position has a significant beneficial effect on the severity of Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) in patients with heart failure (HF). We hypothesized that a reduction in rostral fluid shift from the legs in this position compared with the supine position may contribute to this effect.
Methods: In patients with CSR-CSA and an apnea-hypopnea index (AHI) ≥ 15/h (by standard polysomnography), uncalibrated leg fluid volume was measured in the supine, left lateral decubitus, and right lateral decubitus positions (in-laboratory assessment).
Article Synopsis
- The study investigates how changing positions affects functional residual capacity (FRC) in heart failure patients with Cheyne-Stokes respiration (CSR), focusing on the potential worsening of sleep apnea severity when lying on the back compared to the side.
- Eighteen heart failure patients with CSR underwent tests to measure FRC in different positions and showed significant reductions in FRC when switching from sitting to supine, and a partial recovery when moving to lateral positions.
- The findings suggest that lying supine can worsen respiratory issues during sleep, as reduced FRC is linked to increased apnea events, supporting the theory that body position impacts respiratory control in these patients.
Background: Inspiratory resistive breathing (IRB) challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an interleukin 6 (IL-6)-dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in chronic obstructive pulmonary disease (COPD) is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET) and plasma IL-6 concentration following an IRB challenge.
View Article and Find Full Text PDFObjectives: To explore the mediating role of protein interleukin-6 (IL-6) on the relationship between forced expiratory volume in 1 second (FEV1) and 6-minute walk distance (6MWD) and, further, to determine whether status variables (such as age, sex, and body mass index [BMI]) operate as moderators of this mediation relationship.
Design: Moderated mediation model.
Setting: An inpatient pulmonary rehabilitation center in Italy.
Background: The association between weight loss and Chronic Obstructive Pulmonary Disease (COPD) has been recognised from many years. Based on the evidence that nutritional status reflects metabolic disturbances in COPD, the relationship between body mass index (BMI), severity of airflow obstruction and CO diffusing capacity (DL(CO)), that is the functional hallmark of emphysema, is relevant to the management of COPD phenotypes.
Methods: We reviewed 104 patients with COPD (82 males), aged 66 +/- 9 years (mean +/- SD).