Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma.

Malignant melanoma is one of the most important dermatological neoplasms. The high mortality rate associated with this skin disease is primarily due to the occurrence of metastases, while the diagnosis and treatment of melanoma in its early stages has a favorable prognosis. Early detection is crucial because the success of treatment is directly related to the depth of cancerous growth.

Beyond age: exploring ultimate attainment in heritage speakers and late L2 learners.

According to the Critical Period Hypothesis, successful language learning is optimal during early childhood, whereas language learning outside of this time window is unsuccessful. In this respect, early language acquisition is viewed as convergent and reliable but late acquisition is not. The present study revisits the idea of a critical period by investigating the grammatical attainment of early bilinguals/heritage speakers (HSs), late second/foreign language (L2) learners, and comparable groups of monolinguals by testing Greek-English bilinguals in the two languages they speak by means of a grammaticality judgment task.

Redundancy can hinder adult L2 grammar learning: evidence from case markers of varying salience levels.

Grammatical redundancy is a widespread feature across languages. Although redundant cues can be seen to increase the complexity and processing burden of structures, it has been suggested that they can assist language acquisition. Here, we explored if this learning benefit can be observed from the very initial stages of second language (L2) acquisition and whether the effect of redundancy is modulated by the perceptual salience of the redundant linguistic cues.

Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries.

Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury.

Language Analytic Ability, Print Exposure, Memory and Comprehension of Complex Syntax by Adult Native Speakers.

Nativist theories of language development assume that all native speakers of a particular language ultimately converge on (more or less) the same grammar, and argue that this is only possible because they are born with a genetic blueprint for language. However, a number of recent studies have found that there are, in fact, considerable individual differences in adult native speakers' grammatical attainment. In this study, we examine some possible reasons for these differences.