Publications by authors named "E D Tycksen"
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Antiamyloid antibody treatments modestly slow disease progression in mild dementia due to AD. Emerging evidence shows that homeostatic dysregulation of the brain immune system, especially that orchestrated by microglia, plays an important role in disease onset and progression.
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- Aberrant chondrocyte metabolism plays a key role in cartilage degeneration and osteoarthritis (OA), with carbonic anhydrase 2 (CA2) showing increased expression in OA chondrocytes, though its specific functions are not fully understood.
- This study utilized RNA sequencing on CA2-deficient cells to identify affected metabolic pathways and assessed CA2's influence on chondrocyte metabolism during normal and hypoxic/inflammatory conditions.
- Results revealed that CA2 deficiency impacted glycolysis and cellular functions, highlighting CA2's potential role as a critical regulator of chondrocyte energy metabolism and inflammation in OA, warranting further investigation in animal models.
With aging, bone mass declines and the anabolic effects of skeletal loading diminish. While much research has focused on gene transcription, how bone ages and loses its mechanoresponsiveness at the protein level remains unclear. We developed a novel proteomics approach and performed a paired mass spectrometry and RNA-seq analysis on tibias from young-adult (5-month) and old (22-month) mice.
View Article and Find Full Text PDFBackground: Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions.
Methods: In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human postmortem brain RNA-Seq datasets using both within-region and pan-regional frameworks.
Results: We find evidence of sex-biased transcription in many autosomal genes, some of which provide evidence for pathways and cell population differences between chromosomally male and female individuals.