Publications by authors named "E D Sumner"

Polarizable force fields crucially enhance the modeling of macromolecules in polar media. Here, we present new parameters to model six common monosaccharides with the polarizable AMOEBA force field. These parameters yield a thinner, but denser, hydration layer than that previously reported.

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Article Synopsis
  • The study investigates how the methyltransferase EZH2 is influenced by both chemical signals like TGF-β1 and mechanical signals from stiff environments, impacting gene expression and potentially advancing cancer and fibrosis.
  • Cells cultured on stiff surfaces along with TGF-β1 show increased EZH2 movement to the nucleus and higher levels of a specific histone modification (H3K27me3), which is crucial for regulating gene expression and inducing changes linked to epithelial-mesenchymal transition (EMT).
  • The research suggests that the activity of EZH2 relies on cellular contractility pathways involving Rho-associated kinase (ROCK) and myosin II, highlighting a way that stiffness and TGF-β1 work together to
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The heterogeneity of outcomes in behavioral research has long been perceived as a challenge for the validity of various theoretical models. More recently, however, researchers have started perceiving heterogeneity as something that needs to be not only acknowledged but also actively addressed, particularly in applied research. A serious challenge, however, is that classical psychological methods are not well suited for making practical recommendations when heterogeneous outcomes are expected.

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Lung cancer is the leading cause of cancer related death worldwide and in the United States according to the World Health Organization and National Cancer Institute. Improvements in the diagnosis and treatment of lung cancer are of the utmost importance. A prompt diagnosis is a crucial factor to improve outcomes in the treatment of lung cancer.

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Adults with Developmental Coordination Disorder (DCD), sometimes referred to as dyspraxia, experience difficulties in motor development and coordination, which impacts on all aspects of their daily lives. Surprisingly little is known about the mechanisms underlying the difficulties they experience in the motor domain. In childhood DCD, aspects of oculomotor control have been shown to be altered.

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