[Periodic limb movements in sleep and cerebral small vessel disease progression: a prospective cohort study].

Objective: To determine the predictive role of periodic limb movements in sleep (PLMS) in cerebral small vessel disease (cSVD) progression rate.

Material And Methods: Fifty patients with cSVD, aged 60-75 y.o.

[Molecular and cellular mechanisms of restorative effects of sleep].

The review article enlightens contemporary concept about a role of sleep in cellular energy metabolism, neuroplasticity and glymphatic clearance of waste products. Many researches have demonstrated that prolonged wakefulness is an energetic and a neurophysiologic issue for the brain. The article provides description of biochemical processes that are responsive for energy restoration in sleep, particularly the role of ATP, adenosine and glycogen.

Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study.

Cerebrovascular diseases are the leading cause of cognitive decline and dementia. Therefore, the investigation of the potential ways to slow down the disease progression is an important research field. Periodic limb movements in sleep (PLMS) are known to be associated with transient changes in heart rate and blood pressure.

[Periodic limb movements in sleep and clinicomorphological features of cerebral small vessel disease].

Objective: To search for the association between white matter deterioration extend as well as related cognitive dysfunction and periodic limb movements in sleep (PLMS) in patients with cerebral small vessel disease (cSVD).

Material And Methods: Thirty-four subjects with cSVD were enrolled (12 men, 22 women, average age 66.9 y.