Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.

Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the immunopathology associated with each phenotype. Although defective T and B cell development is common to all phenotypes, patients with hypomorphic variants can generate T and B cells with signatures of immune dysregulation and produce autoantibodies to a broad range of self-antigens, including type I interferons.

Differentiated thyroid cancer in adolescents - does extent of disease at presentation differ with age?

Objectives: The authors sought to assess whether the age of 18 reflects a true pathological inflection point that justifies transitioning between pediatric and adult paradigms of care with differentiated thyroid cancer (DTC).

Methods: A retrospective chart review was conducted for patients aged 12-24 undergoing hemithyroidectomy or total thyroidectomy for papillary or follicular thyroid carcinoma from 2010 to 2020.

Results: A total of 153 patients receiving surgery for DTC were assessed for pathological stage, nodal metastasis, and thyroid neoplasm characteristics.

Atmospheres of influence: the role of journal editors in shaping early climate change narratives.

The role of editorial staff in shaping early climate change narratives has been underexplored and deserves more attention. During the 1970s, the epistemological underpinnings of the production of knowledge on climate change were contested between scientists who favoured computer-based atmospheric simulations and those who were more interested in investigating the long-term history of climatic changes. Although the former group later became predominant in the Intergovernmental Panel on Climate Change during the 1980s, the latter had a sizable influence over climate discourse during the 1970s.

Improving Consistency in Classifying Child Maltreatment for Sudden Unexpected Infant Deaths.

Objective: Develop guidelines for child death review teams that will improve the consistency in classifying child maltreatment (CM) and distinguish between classification of exposure to hazards and neglect for sleep-related sudden unexpected infant deaths (SUID).

Methods: Sleep-related SUID (n = 25 797) were identified from the National Fatality Review-Case Reporting System between 2004 and 2018. Key variables considered when classifying CM among sleep-related SUID were identified.