The Current and Future State of Vaccines for Lyme Disease.

Lyme disease is caused by Borrelia species that are transmitted by Ixodes ticks prevalent in parts of the United States and Europe. A Lyme vaccine containing the OspA antigens from the single Borrelia species most prevalent in the United States was marketed in the 1990s, but was withdrawn because of unproven concerns about safety, which led to insufficient sales. Since then, the incidence of Lyme disease has increased in the United States owing to the geographical spread of infected ticks.

Evaluation of the ASPYRE-Lung targeted variant panel: a rapid, low-input solution for non-small cell lung cancer biomarker testing and experience from three independent sites.

Background: Many patients with non-small cell lung cancer (NSCLC) lack access to highly effective approved targeted therapeutics due to multiple gaps in biomarker testing. Challenges in comprehensive molecular testing include complexities associated with the need to assess the presence of multiple variants, costs of running multiple sequential assays per sample, high assay quality control (QC) failure rates, clinical need for rapid turn-around time (TAT) to initiate therapy, and insufficient tissue samples. The ASPYRE-Lung NSCLC assay addresses gaps in multiplexed testing by simultaneously analyzing DNA and RNA, detecting 114 actionable genomic variants across 11 genes, consistent with current NSCLC treatment guidelines.

Device Design and Advanced Computed Tomography of 3D Printed Radiopaque Composite Scaffolds and Meniscus.

3D printed biomaterial implants are revolutionizing personalized medicine for tissue repair, especially in orthopedics. In this study, a radiopaque bismuth oxide (BiO) doped polycaprolactone (PCL) composite is developed and implemented to enable the use of diagnostic X-ray technologies, especially spectral photon counting X-ray computed tomography (SPCCT), for comprehensive tissue engineering scaffold (TES) monitoring. PCL filament with homogeneous BiO nanoparticle (NP) dispersion (0.

How clinical exposure improves dental students' understanding of oral and maxillofacial surgery: A cross-sectional study.

Purpose: To assess dental students' understanding of oral and maxillofacial surgery (OMFS) practice areas and examine changes in referral preferences across their educational progression in Israel.

Methods: A cross-sectional survey was conducted among 349 dental students from two Israeli universities (46.5% response rate).

United for change: deliberative coalition formation to change the status quo.

We study a setting in which a community wishes to identify a strongly supported proposal from a space of alternatives, in order to change the status quo. We describe a deliberation process in which agents dynamically form coalitions around proposals that they prefer over the status quo. We formulate conditions on the space of proposals and on the ways in which coalitions are formed that guarantee deliberation to succeed, that is, to terminate by identifying a proposal with the largest possible support.