Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells.

Ulcerative colitis is a chronic relapsing-remitting and potentially progressive form of inflammatory bowel disease in which there is extensive inflammation and mucosal damage in the colon and rectum as a result of an abnormal immune response. MV130 is a mucosal-trained immunity-based vaccine used to prevent respiratory tract infections in various clinical settings. Additionally, MV130 may induce innate immune cells that acquire anti-inflammatory properties and promote tolerance, which could have important implications for chronic inflammatory diseases such as ulcerative colitis.

Atmospheric reaction of CH=CHCHOCFCHF with OH radicals and Cl atoms, UV and IR absorption cross sections, and global warming potential.

In this work, the rate coefficients for OH radical, k(T), and Cl atom, k(T), reaction with allyl 1,1,2,2-tetrafluoroethyl ether, CH=CHCHOCFCHF, were studied as a function of temperature and pressure in a collaborative effort made between UCLM, Spain, and LAPKIN, Greece. OH rate coefficients were determined in UCLM, between 263 and 353 K and 50-600 Torr, using the absolute rate method of pulsed laser photolysis-laser-induced fluorescence technique, while Cl kinetics were studied in temperature (260-363 K) and pressure (34-721 Torr) ranges, using the relative rate method of the thermostated photochemical reactor equipped with Fourier transform infrared spectroscopy as the detection technique. In both OH and Cl reactions, a negative temperature dependence of the measured rate coefficients was observed, which is consistent with complex association reactions.