Mental imagery for addressing mechanisms underlying motor impairments in children with attention deficit hyperactivity disorder (ADHD).

Children with attention deficit hyperactivity disorder (ADHD) exhibit various degrees of motor and cognitive impairments in fine and gross motor skills. These impairments impact social functioning, while also hindering academic achievement, self-esteem, and participation. Specifically, motor impairments are not fully addressed by current therapies.

Proteomic analysis of the pyrenoid-traversing membranes of reveals novel components.

Pyrenoids are algal CO-fixing organelles that mediate approximately one-third of global carbon fixation and hold the potential to enhance crop growth if engineered into land plants. Most pyrenoids are traversed by membranes that are thought to supply them with concentrated CO. Despite the critical nature of these membranes for pyrenoid function, they are poorly understood, with few protein components known in any species.

SAGA1 and MITH1 produce matrix-traversing membranes in the CO-fixing pyrenoid.

Approximately one-third of global CO assimilation is performed by the pyrenoid, a liquid-like organelle found in most algae and some plants. Specialized pyrenoid-traversing membranes are hypothesized to drive CO assimilation in the pyrenoid by delivering concentrated CO, but how these membranes are made to traverse the pyrenoid matrix remains unknown. Here we show that proteins SAGA1 and MITH1 cause membranes to traverse the pyrenoid matrix in the model alga Chlamydomonas reinhardtii.

The Alzheimer's Disease Neuroimaging Initiative Neuropathology Core: An update.

Introduction: Biomarkers for Alzheimer's disease neuropathologic change (ADNC) have been instrumental in developing effective disease-modifying therapeutics. However, to prevent/treat dementia effectively, we require biomarkers for non-AD neuropathologies; for this, neuropathologic examinations and annotated tissue samples are essential.

Methods: We conducted clinicopathologic correlation for the first 100 Alzheimer's Disease Neuroimaging Initiative (ADNI) Neuropathology Core (NPC) cases.

Biogenesis, engineering and function of membranes in the CO -fixing pyrenoid.

Approximately one-third of global CO assimilation is performed by the pyrenoid , a liquid-like organelle found in most algae and some plants . Specialized membranes are hypothesized to drive CO assimilation in the pyrenoid by delivering concentrated CO , but their biogenesis and function have not been experimentally characterized. Here, we show that homologous proteins SAGA1 and MITH1 mediate the biogenesis of the pyrenoid membrane tubules in the model alga and are sufficient to reconstitute pyrenoid-traversing membranes in a heterologous system, the plant .