Publications by authors named "E D COWEN"
Objective: To investigate the effects of oral baricitinib on ocular surface disease (OSD) in patients with chronic graft-versus-host disease (cGVHD).
Design: Prospective phase 1 to 2 single institution trial.
Subjects: Eighteen patients with ocular graft-versus-host-disease (oGVHD) and systemic steroid-refractory cGVHD.
Article Synopsis
- Cutaneous chronic graft-versus-host disease (cGVHD) frequently occurs after hematopoietic stem cell transplants, leading to significant health issues and a lower quality of life for affected individuals.
- The condition can present in varied ways, categorized into nonsclerotic and sclerotic types, with specific challenges noted for patients with skin of color.
- Effective management requires collaboration between transplant specialists and dermatologists, emphasizing the importance of proper diagnosis, treatment, and ongoing skin care for long-term recovery.
Article Synopsis
- - Patients with GATA2 haploinsufficiency face higher risks for HPV-related anogenital cancers, with the study showing that HPV appeared at a median age of 18.9 in females and 25.6 in males, often leading to significant health issues.
- - The research conducted a thorough review of 68 patients over 17 years, revealing that 76% had HPV-related squamous intraepithelial lesions (SIL), with females showing a higher prevalence and severity of high-grade lesions compared to males.
- - Among patients receiving hematopoietic stem cell transplants for GATA2-linked diseases, some still experienced persistent HPV issues post-treatment; however, those who received vaccinations afterward showed minimal evidence
Article Synopsis
- * The research found that tissue samples from patients showed strong IFN-I (a type of immune response) activity and signs of inflammation, even when the virus was only minimally present in biopsies.
- * Additionally, an experiment using hamsters demonstrated that while the virus was active in the lungs, local IFN-I responses occurred in other areas (like toes) without the body developing traditional immunity to the virus, suggesting a potential viral trigger for some pernio cases.