Publications by authors named "E D Burstein"
During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.
View Article and Find Full Text PDFArticle Synopsis
- * PGLYRP-1 is essential for innate immune response in macrophages when triggered by a specific PGN disaccharide (GMTriP-K), but not by other similar compounds, indicating a unique signaling pathway.
- * The study found that PGLYRP-1 interacts with other proteins in cells, localizes to specific cellular structures, and is involved in regulating gene expression linked to intestinal inflammation in both mice and humans.
Two complimentary techniques were used to estimate occupancy of pimavanserin (a selective 5-HT inverse agonist) to 5-HT and 5-HT receptors in non-human primate brains. One employed the 5-HT selective radioligand [C]CIMBI-36 combined with quantification of binding potentials in brain regions known to be enriched in 5-HT (cortex) or 5-HT (choroid plexus) receptors to estimate occupancy. Pimavanserin was 6-10 fold more potent displacing [C]CIMBI-36 from cortex (ED = 0.
View Article and Find Full Text PDFNutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs.
View Article and Find Full Text PDF