Survey Report on Complaints Related to the Interconnectivity between Vial Containers and Transfer Devices.

To address the challenges related to the interconnectivity between vial container closure systems and vial transfer devices, pharmaceutical, elastomer, and transfer device manufacturers have formed a working group under the Product Quality Research Institute (PQRI) to establish best practices for the evaluation of the assembly of vial transfer devices and vial systems. As part of the project, the first activity was to quantify the nature and frequency of issues (complaints). To this end, the working group conducted a survey with questionnaires related to categories and numbers of complaints, regions/countries where complaints were received, and the nature of the manufacturers who received the complaints.

A 15-year survey of chronic lung disease of prematurity.

The in-hospital findings for infants of 500-1,500 g birthweight admitted for intensive care over the years 1971-87 were reviewed at four intervals. Survival rate improved substantially. The incidence of chronic lung disease (CLD) in survivors at 28 days of age was unchanged though severity diminished in terms of both mortality and degree of radiographic change.

Persistent pulmonary hypertension of the newborn treated with hyperventilation: clinical features and outcome.

Twenty-seven infants with severe persistent pulmonary hypertension of the newborn were seen in 33 months. Asphyxia with or without meconium aspiration was the cause in the majority of cases. Other causes were group B streptococcal sepsis and acute fetal blood loss.

Antenatal and intrapartum events influencing outcome in very low birth-weight infants.

The influence of antenatal and intrapartum events and the route of delivery on Apgar scores and short-term outcome was studied in 359 singleton very low birth-weight infants who were resuscitated adequately at birth and had no lethal congenital anomalies. When stratified according to gestation the occurrence of antepartum haemorrhage, pregnancy-induced hypertension and amnionitis had no influence on the outcome while cord prolapse in infants less than 26 weeks resulted in 100% mortality. Prolonged rupture of membranes significantly improved the chances of their survival.