Sex differences in ischemic stroke during COVID-19 first outbreak in northern Italy.

Introduction: COVID-19 pandemic had a great impact on outcome in SARS-CoV-2 positive patients with ischemic stroke during the first wave in Italy. Few data are available on outcome stratified by sex.

Methods: The Italian Society of Hospital Neuroscience conducted a multi-center, retrospective, observational study on neurological complications in COVID-19 patients with ischemic stroke.

COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy).

Objective: To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the first pandemic wave, Lombardia.

Methods: Adult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).

Results: Thirty-eight COVID19-GBS patients had a mean age of 60.

Erenumab Discontinuation After 12-Month Treatment: A Multicentric, Observational Real-Life Study.

Objective: To assess migraine outcome after 12-month treatment with erenumab and compare patients who underwent 3-month erenumab discontinuation following the first treatment cycle with those who continued monthly administrations.

Methods: This is a multicentric observational study in patients with migraine in treatment with erenumab. After a full 12-month treatment cycle (T), patients could either continue or discontinue erenumab for at least 3 months.

Genetic and epigenetic disease modifiers in an Italian family expressing ALS, FTD or PD clinical phenotypes.

The presence of the hexanucleotide repeat expansion (HRE) in gene is associated to the ALS/FTD spectrum, but also to parkinsonisms. We here describe an Italian family with the father diagnosed with Parkinson disease (PD) at the age of 67 and the two daughters developing FTD and ALS at 45 years of age. We searched for HRE with possible genetic and epigenetic modifiers to account for the intrafamilial phenotypic variability.