Publications by authors named "E Cugat"
DOse and administration Time of Indocyanine Green in near-infrared fluorescence cholangiography during laparoscopic cholecystectomy (DOTIG): a randomized clinical trial.
Surg Endosc
March 2025
Background: Different techniques have been proposed to reduce the incidence of the intraoperative bile duct injury during laparoscopic cholecystectomy (LC). Among these, Near-Infrared Fluorescence Cholangiography (NIFC) with Indocyanine Green (ICG) represents a relatively recent addition. At present, there is considerable variation in the protocols for the administration of ICG.
View Article and Find Full Text PDFIntroduction: A positive surgical margin (R1 resection) is a relevant risk factor for local recurrence in patients with pancreatic ductal adenocarcinoma of the pancreas (PDAC). An intraoperative liquid biopsy (ILB) based on tumor cell mobilization could help to detect R1 resection intraoperatively.
Objective: To evaluate the potential role of the intraoperative circulating tumor cells (CTCs) and cluster mobilization on the R0/R1 detection.
Article Synopsis
- The study investigates two surgical approaches (no-touch vs. superior mesenteric artery) in patients undergoing pancreatoduodenectomy for pancreatic ductal adenocarcinoma, focusing on circulating tumor cells during surgery.
- *Patients were randomly assigned to each group, and samples were taken to measure tumor cell activity at different surgical stages.
- *Results showed no significant differences in tumor cell mobilization or metastasis-free survival between the two approaches, but patients with tumor cell clusters mobilized during surgery had a higher rate of distant metastases within the first year.