Publications by authors named "E Csizmadia"
1,5-hydride transfer-triggered cyclization reactions offering a robust method for C(sp)-C(sp) coupling and the synthesis of tetrahydroquinolines have been thoroughly investigated in the literature. Catalysts allowing milder reaction conditions or the development of enantioselective processes were important recent contributions to the field, as well as the studies on subtrates with oxygen or sulfur heteroatoms (besides the originally described nitrogen heterocycles). In a series of studies, we focused on expanded, higher order H-transfers/cyclizations by positioning the interacting substituents on distanced rings.
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- Lung cancer, particularly lethal pulmonary adenocarcinomas, often shows mutations in the EGFR gene, making understanding tumor behavior and treatment important.
- Researchers utilized genetically engineered mice to study how tumors evolve and interact with their surrounding environment, identifying specific vulnerable cells and their communication with other cells in the tumor microenvironment.
- The drug Unesbulin, a tubulin binding agent, was found to decrease tumor growth and alter the interactions within the tumor environment, suggesting it could be a promising therapeutic strategy for treating EGFR-mutant lung cancers.
Th17-cells play a key role in the pathogenesis of autoimmune hepatitis (AIH). Dysregulation of Th17-cells in AIH is linked to defective response to aryl-hydrocarbon-receptor (AhR) activation. AhR modulates adaptive immunity and is regulated by aryl-hydrocarbon-receptor-repressor (AHRR), which inhibits AhR transcriptional activity.
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- Researchers found that cancer treatments like radiation and chemotherapy can cause inflammation and bleeding in the gut.
- They noticed that certain immune cells called macrophages and a protein called hemopexin were more present in patients who experienced these issues.
- In experiments with mice, they discovered that a lack of hemopexin led to more DNA damage and inflammation in gut cells, which could help explain the problems some patients have after treatment.