Alkyl Formates as Transfer Hydroalkylation Reagents and Their Use in the Catalytic Conversion of Imines to Alkylamines.

Easily accessible via a simple esterification of alcohols with formic acid, alkyl formates are used as a novel class of transfer hydroalkylation reagents, CO acting as a traceless linker. As a proof-of-concept, their reactivity in the transfer hydroalkylation of imines is investigated, using a ruthenium-based catalyst and LiI as promoter to cleave the C-O σ-bond of the formate scaffold. Providing tertiary amines, the reaction displays a divergent regioselectivity compared to previously reported transfer hydroalkylation strategies.

Posttraumatic stress as a contributor to behavioral health outcomes and healthcare utilization in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Purpose: To examine the association between posttraumatic stress symptoms (PTSS), neurocognitive and psychosocial late-effects, health behaviors, and healthcare utilization in long-term survivors of childhood cancer.

Methods: Participants included individuals (N = 6844; 52.5% female; mean [SD] age at diagnosis = 7.

The optimal indication for FiLaC is high trans-sphincteric fistula-in-ano: a prospective cohort of 69 consecutive patients.

Background: The aim of our study was to prospectively evaluate the effectiveness of the Fistula Laser Closure (FiLaC) technique in patients at high risk of anal incontinence and to determine the predictors of success and the impact of the procedure on anal continence.

Methods: A prospective study was conducted on all patients treated with FiLaC in our department in May 2016-April 2017, because they were at high risk of anal incontinence after fistulotomy, The fistula was considered healed when the internal and external openings were closed and the patient experienced was no pain or leakage.

Results: A total of 69 consecutive patients (34 males) with a median age of 40 years (33-53 years) were included in the study.