Publications by authors named "E Cresswell"
Article Synopsis
- Blood-CNS barriers help protect the central nervous system (CNS) by blocking immune cells and harmful molecules, but their integrity may decline with age, impacting CNS function.
- Research showed that aging primarily affects genes linked to immune responses and pericyte function in certain CNS regions, particularly the spinal cord, but does not significantly alter endothelial cell junctions or vascular structures.
- The study found no evidence of increased paracellular permeability in blood-brain and blood-spinal cord barriers with normal aging in mice, suggesting that while gene expression changes occur, they do not directly lead to permeability issues unless there are additional stressors.
Objective: To describe the development and maturation of equine proximal sesamoid bones (PSBs) in fetuses and young horses using radiography, microcomputed (micro)-CT, and histology.
Methods: A descriptive study. Forelimb PSBs from 12 equids ranging in age from 105 days of gestation to 540 days postgestation were evaluated.
Upper-body adiposity is adversely associated with metabolic health whereas the opposite is observed for the lower-body. The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown adipose tissue (BAT), which is increasingly recognised to influence whole-body metabolic health. Loss of BAT, concurrent with replacement by white adipose tissue (WAT), may contribute to metabolic disease, and specific accumulation of neck fat is seen in certain conditions accompanied by adverse metabolic consequences.
View Article and Find Full Text PDFCholinergic circuits in the central nervous system are vulnerable to age-related functional decline, but it is not known if aging impacts cholinergic signaling in the vestibular sensory organs, which are critically important to balance maintenance and visual gaze stability. We have previously shown cholinergic neurotransmission between vestibular efferent terminals and type II mechanosensory hair cells requires the alpha9 (Chrna9) nicotinic receptor subunit. Homozygous knockout of the alpha9 subunit causes vestibulo-ocular reflex adaptation deficits that mirror those observed in aged mice.
View Article and Find Full Text PDFSodium channel expression in inner ear afferents is essential for the transmission of vestibular and auditory information to the central nervous system. During development, however, there is also a transient expression of Na channels in vestibular and auditory hair cells. Using qPCR analysis, we describe the expression of four Na channel genes, SCN5A (Nav1.
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