Publications by authors named "E Crawley"
Article Synopsis
- The study aimed to compare the effectiveness of a web-based cognitive-behavioral therapy program called "Fatigue In Teenagers on the interNET" with videocall-delivered activity management for adolescents aged 11-17 with myalgic encephalomyelitis/chronic fatigue syndrome.
- Adolescents in the trial received either treatment for six months, and the effectiveness was measured using the 36-item Short Form Health Survey Physical Function subscale.
- The trial involved random assignment of 314 adolescents, although participants and their families could not be blinded to their treatment group.
The MAGENTA pragmatic parallel groups randomized controlled trial compared graded exercise therapy (GET) with activity management (AM) in treating paediatric myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Children aged 8-17 years with mild/moderate ME/CFS and presenting to NHS specialist paediatric services were allocated at random to either individualised flexible treatment focussing on physical activity (GET, 123 participants) or on managing cognitive, school and social activity (AM, 118 participants) delivered by NHS therapists. The primary outcome was the self-reported short-form 36 physical function subscale (SF-36-PFS) after 6 months, with higher scores indicating better functioning.
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- Conventional channel-based microfluidic platforms are commonly used to create phospholipid nanostructures like liposomes, but they face scalability issues.
- A vortex fluidic device (VFD) offers a solution by using a thin film microfluidic approach, enabling the production of ~110 nm diameter liposomes through a high-yield, continuous flow process.
- The VFD can also facilitate the labeling of liposomes and study their stability and behavior under shear stress, revealing that ~110 nm liposomes are typically the most stable structures formed through self-assembly, similar to exosome sizes.
This study emphasises the critical role of quality sleep in physical and mental well-being, exploring its impact on bodily recovery and cognitive function. Investigating poor sleep quality in approximately 40% of individuals with insomnia symptoms, the research delves into its potential diagnostic relevance for depression and anxiety, with a focus on intervention in mental health by understanding sleep patterns, especially in young individuals. This study includes an exploration of phone usage habits among young adults during PPI sessions, providing insights for developing the SleepTracker app.
View Article and Find Full Text PDFPurpose: To explore the views of clinicians and researchers about the challenges of measuring health-related quality of life (HRQoL) in children (5-11 years) and to explore whether digital ecological momentary assessment (EMA) could enhance HRQoL measurement.
Methods: Semi-structured qualitative interviews with 18 professionals (10 academics/researchers, four clinicians, four with both professional backgrounds) experienced in child HRQoL measurement. We analysed data thematically.