Publications by authors named "E Cozzani"
Article Synopsis
- Dimethyl fumarate (DMF) is an oral medication approved for treating moderate-to-severe plaque psoriasis in adults.
- The study evaluated 92 patients without prior systemic therapy to see how their demographics and medical characteristics affected DMF's efficacy and side effects.
- Results showed significant improvement in psoriasis symptoms within 4 weeks, with younger patients responding better to treatment, while factors like gender and BMI didn't significantly influence side effects.
Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas, and anogenital warts. Severe systemic side effects associated with imiquimod 5% cream are rare, although a few cases of erythema multiforme and Stevens-Johnson syndrome have been described. We present a case of Stevens-Johnson syndrome associated with topical treatment with imiquimod of two superficial basal cell carcinomas.
View Article and Find Full Text PDFBackground: Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare autoimmune blistering disorders characterized by autoantibodies (autoAbs) targeting dermo-epidermal junction components such as BP180 and BP230. The differential diagnosis, based on both the time of appearance and the extension of cutaneous and/or mucosal lesions, is crucial to distinguish these diseases for improving therapy outcomes and delineating the correct prognosis; however, in some cases, it can be challenging. In addition, negative results obtained by commercially available enzyme-linked immunosorbent assays (ELISAs) with BP and MMP sera, especially from patients with ocular involvement, often delay diagnosis and treatment, leading to a greater risk of poor outcomes.
View Article and Find Full Text PDFImpact of Psoriasis on Pregnancy Desire and Possible Consequences on Fertility.
Dermatol Pract Concept
October 2024
Introduction: Approximately half of patients affected by psoriasis are women, and the management of female patients of childbearing age is an under-investigated topic. Some studies have shown a significant decrease in births in psoriatic patients due to intimacy and pregnancy avoidance and to potential birth complications.
Objectives: We sought to evaluate data on reproductive health in a cohort of female patients, to compare them with similar data in the general population and to assess the impact of psoriasis, especially genital psoriasis, on pregnancy desire and the prevalence of psoriasis in the children of patients with psoriasis.
Eczematous reactions in patients with plaque psoriasis receiving biological therapy: an observational study.
Eur Rev Med Pharmacol Sci
September 2024
Article Synopsis
- The study investigated eczematous reactions in psoriasis patients treated with biologic agents, specifically TNF-α and IL-17A inhibitors, highlighting the lack of complete understanding of these side effects.
- Conducted in Italy with 54 patients, the research noted that many had personal or family histories of atopy, and eczema could appear within days to years after starting treatment, with a notable number of cases linked to anti-IL-17 therapies.
- The findings suggest switching to IL-23 inhibitors can lead to rapid eczema remission without relapse, indicating such treatments may be preferable for patients with a history of atopic dermatitis.