Publications by authors named "E Coutinho"
Twelve-lead ambulatory ECG recording using a seven-electrode recorder: An alternative method for electrophysiological evaluation.
Indian Pacing Electrophysiol J
October 2024
Introduction: Conventional three-lead ambulatory electrocardiogram recording (3L-AECG) is used for the quantitative diagnosis of arrhythmias. However, the lack of crucial information, such as QRS morphology and orientation, renders the 3L-AECG incomplete for planning electrophysiological interventions. The 12-lead AECG (12L-AECG) merges the temporal resolution 3L-AECG with the spatial resolution of the standard electrocardiogram (S-ECG).
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- Puberty marks a key transition to reproductive capability and is driven by the activation of gonadotropin-releasing hormone (GnRH) neurons, with kisspeptin neurons likely playing a role in this activation.
- Researchers selectively removed arcuate kisspeptin neurons (KNDy neurons) in juvenile mice to study their influence on the timing of puberty, finding that their absence led to delayed puberty and lower hormone levels.
- The study concluded that while most KNDy neurons are critical for the timing of puberty onset, a smaller subset is sufficient for normal GnRH pulse timing, and full KNDy neuron functionality is not necessary for generating the LH surge in females.
Background: Severe psychomotor agitation and aggression often require immediate pharmacological intervention, but clear evidence-based recommendations for choosing among the multiple options are lacking. To address this gap, we plan a systematic review and individual-participant-data network meta-analysis to investigate their comparative effectiveness in real-world emergency settings with increased precision.
Methods: We will include randomized controlled trials investigating intramuscular or intravenous pharmacological interventions, as monotherapy or in combination, in adults with severe psychomotor agitation irrespective of the underlying diagnosis and requiring rapid tranquilization in general or psychiatric emergency settings.
Study Question: Do hyperactive kisspeptin neurons contribute to abnormally high LH secretion and downstream hyperandrogenemia in polycystic ovary syndrome (PCOS)-like conditions and can inhibition of kisspeptin neurons rescue such endocrine impairments?
Summary Answer: Targeted inhibition of endogenous kisspeptin neuron activity in a mouse model of PCOS reduced the abnormally hyperactive LH pulse secretion and hyperandrogenemia to healthy control levels.
What Is Known Already: PCOS is a reproductive disorder characterized by hyperandrogenemia, anovulation, and/or polycystic ovaries, along with a hallmark feature of abnormal LH hyper-pulsatility, but the mechanisms underlying the endocrine impairments remain unclear. A chronic letrozole (LET; aromatase inhibitor) mouse model recapitulates PCOS phenotypes, including polycystic ovaries, anovulation, high testosterone, and hyperactive LH pulses.