A 4-year follow-up of root canal obturation using a calcium silicate-based sealer and a zinc oxide-eugenol sealer: A randomized clinical trial.

Aim: This randomized clinical trial assessed the outcomes of nonsurgical root canal treatment (RCT), comparing a calcium silicate-based sealer (CSBS) with the single-cone technique (SC) with a zinc oxide-eugenol (ZOE) sealer and warm vertical compaction (WVC).

Methodology: Ninety-two single- and multi-rooted teeth were divided into two groups and treated using either the SC with BioRoot™ RCS (BIO) or WVC with Pulp Canal Sealer™ EWT (PCS). Teeth with apical periodontitis (AP) in both groups were further divided into BIOAP and PCSAP subgroups.

Endodontic treatment modifies circulatory inflammatory mediator levels: A systematic review with meta-analysis.

Background: There is limited and conflicting data on the reduction of circulatory inflammatory mediators in patients with apical periodontitis (AP) following endodontic treatment.

Objective: To answer the following research question: in adult healthy patients with AP [Population (P)], is there a difference before [Comparator (C)] and after various endodontic treatments (nonsurgical, surgical or retreatment) [Intervention (I)] on systemic levels of inflammatory biomarkers [Outcome (O)] in the follow-up period [Time (T)]?

Methods: An electronic literature search was conducted in the databases Scopus, PubMed, Clarivate Analytics' Web of Science, Cochrane Database of Systematic Reviews and Grey literature from inception to July 2024 with no language restrictions. Observational studies examining changes in serum levels of inflammatory mediators were included.

Evidence of an effect of statins on lesions originating from dental infection. A retrospective clinical investigation.

Background: Apical periodontitis (AP) is an inflammatory dental disease caused by bacterial infections of the endodontic system. The correlation between AP and cardiovascular diseases. (CVD) has been consistently investigated.

Prevalence of Apical Periodontitis in Patients with Autoimmune Liver Diseases on Immune Suppressants and Immune Modulators: A Cross-sectional Study.

Introduction: Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated autoaggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of apical periodontitis (AP) in patients suffering from ALDs undergoing treatment with the immune suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid.

Methods: The ALD group included 46 patients (11 men and 35 women, average age = 57.

What is new in the 2023 European Society of Endodontology S3-level clinical practice guidelines?

Background: The European Society of Endodontology published in 2023, the S3-level clinical practice guidelines, which supersede the Quality Guidelines for Endodontic Treatment published in 2006.

Objectives: This review aims to summarize and compare the above guidelines to support their dissemination.

Method: A narrative synthesis of the main differences alongside tabulation according to the main themes.