Publications by authors named "E Corden"
Article Synopsis
- Mitochondria don't use nucleotide excision DNA repair, but their DNA (mtDNA) shows resilience against mutations after DNA damage, hinting at protective mechanisms.
- Research involved techniques like live-cell imaging and protein-DNA binding assays to study how Transcription Factor A, Mitochondrial (TFAM) interacts with UVC-damaged DNA and its effects on mtDNA.
- Results showed TFAM increases mtDNA compaction when damaged, but surprisingly, this doesn't prevent further DNA damage or mutations, suggesting TFAM's role as a damage sensor rather than a protective agent.
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposing atopic dermatitis patients to house dust mite. Here we analyse transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of cutaneous immunocytes revealed a distinct dichotomy in atopic dermatitis patient responsiveness to house dust mite challenge.
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- - The study explored how environmental factors affect child health in rural Pakistan, particularly focusing on acute respiratory infections (ARIs), diarrhea, and growth, using geographical information systems (GIS) technology.
- - Data from 416 children revealed that those living closer to secondary hospitals and Maternal Health Centers (MHCs) experienced lower rates of ARIs and diarrhea compared to those near primary healthcare facilities.
- - The findings suggest that distance to healthcare facilities significantly impacts disease prevalence, indicating potential gaps in public policy that could improve health outcomes in rural areas.
Objectives: To determine the presenting features of ocular surface disease in patients with atopic dermatitis (AD) treated with dupilumab at a tertiary, university hospital. To establish the need for treatment of dupilumab-associated ocular surface disease and report any long-term effects on the ocular surface.
Methods: A retrospective analysis of consecutive patients treated with dupilumab for AD between January 2017 and August 2019 was undertaken.