Publications by authors named "E Connick"

Adherence to antiretroviral therapy (ART) is crucial for achieving and maintaining viral suppression in people living with HIV (PLWH). While individual factors affecting HIV viral suppression have been extensively studied, there is less attention on community-level factors, specifically perceived neighborhood disorder. This study aims to assess the relationship between perceived neighborhood disorder and achieving virologic suppression among people living with HIV.

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Article Synopsis
  • A study on the effects of statin therapy in people living with HIV (PWH) found that while it did not reduce the overall incidence of COVID-19, it may lower the risk of severe cases of COVID-19 before vaccination.
  • The study analyzed data from 6,905 PWH and included variables such as age, gender, and race, showing that a majority had received COVID-19 vaccinations by the end of the study period.
  • Statin therapy demonstrated a potential protective effect against serious COVID-19 cases, as evidenced by a hazard ratio of 0.75, but the results were inconclusive due to fewer cases than expected.
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In secondary lymphoid tissues, human immunodeficiency virus (HIV) can replicate in both the follicular and extrafollicular compartments. Yet, virus is concentrated in the follicular compartment in the absence of antiretroviral therapy, in part due to the lack of cytotoxic T lymphocyte (CTL)-mediated activity there. CTLs home to the extrafollicular compartment, where they can suppress virus load to relatively low levels.

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Recognizing challenges faced by people living with HIV is vital for improving their HIV treatment outcomes. While individual-level interventions play a crucial role, community factors can shape the impact of individual interventions on treatment outcomes. Understanding neighborhood characteristics' association with HIV treatment outcomes is crucial for optimizing effectiveness.

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  • The study aimed to evaluate the effectiveness of the mRNA-1273 vaccine against SARS-CoV-2 infection in young adults aged 18-29 who had never been infected or vaccinated before.
  • Over 1,149 participants received the vaccine, and the results showed a 52.6% efficacy against infection and 71.0% efficacy against symptomatic COVID-19, primarily due to the Delta variant.
  • Despite the positive findings, the incidence of infection was higher in a separate group that declined vaccination, indicating that other factors also played a role in infection risk.
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