Publications by authors named "E Condom"
Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling has been associated with neoplastic cell growth and cancer.
View Article and Find Full Text PDFObjective: To describe the initial experiencein our center on targeted prostate biopsies (TB) using Magnetic Resonance imaging/ultrasonography (MRI/US) fusion and to compare PCa detection with systematic biopsies (SB).
Patients And Me Thods: A retrospective, descriptive and comparative study was conducted on the first 94 men who underwent TB using MRU/US fusion in our center since February 2017 to March 2018. All patients underwent a protocol of 6-12 cores of systematic biopsies (SB) (except 9) and 2-6 targeted coreson the MRI index lesion.
Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control.
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- Researchers studied the genetic causes of cisplatin resistance in testicular germ cell tumors by transplanting human tumors into mice, which maintained key tumor characteristics and drug sensitivity.
- They found that tumors resistant to cisplatin showed specific chromosomal alterations, particularly gains in the 9q32-q33.1 region, which were associated with poorer survival rates in patients.
- The study identified several deregulated genes in the resistant tumors and suggested that inhibiting the glucosylceramide synthase (GCS) could help overcome cisplatin resistance, highlighting the potential of orthoxenografts for drug testing and identifying resistance markers.
Article Synopsis
- Marfan syndrome (MFS) causes problems with blood vessels, specifically aortic aneurysms, due to improper proteins and signaling in the body.
- Scientists studied a protein called NOX4 that is linked to these aneurysms to understand how it affects their growth and structure in mice with MFS.
- They found that NOX4 helps damage the blood vessels in MFS, and blocking it can make the vessels stronger and healthier.