Publications by authors named "E Conde"
Article Synopsis
- Glypican-3 (GPC3) is a potential target for T-cell therapy in hepatocellular carcinoma (HCC), but current CAR T-cell approaches face issues like low persistence and GPC3 shedding.
- Researchers immunized HLA-A2 transgenic mice to find GPC3-specific T-cell receptors (TCRs) and engineered human T cells (TCR-Ts) that effectively recognize GPC3-positive HCC cells.
- TCR-B-T cells showed superior effectiveness compared to traditional CAR T-cells, and combining CAR-T and TCR-B-T cells may enhance therapeutic results in treating HCC.
Article Synopsis
- - The study analyzed brain dynamics in 10 individuals with pharmacoresistant focal epilepsy and 30 healthy controls using resting-state functional MRI, focusing on how seizures start and spread.
- - Findings revealed significant changes in global brain connectivity, with increased integration and flexibility, and specific regions showing paradoxical decreases in ignition within the seizure onset zone.
- - The results contribute to a better understanding of epilepsy mechanisms and may help in creating diagnostic tools and therapies for seizure management.
Aims: To study programmed death ligand 1 (PD-L1) expression and tumour infiltrating lymphocytes (TILs) in patients with early-stage non-small cell lung carcinoma (NSCLC) with artificial intelligence (AI) algorithms.
Methods: The study included samples from 50 early-stage NSCLCs. PD-L1 immunohistochemistry (IHC) stained slides (clone SP263) were scored manually and with two different AI tools (PathAI and Navify Digital Pathology) by three pathologists.
Globally, challenges with water and food are two of the most pressing problems people face. Yet hydrologically water-rich environments and rural environments are often overlooked in these discussions due to abundance of natural water resources. Here we test the relationship between water and food insecurity among 270 Tsimane' households in the Bolivian Amazon.
View Article and Find Full Text PDFBackground: Studies have shown that an emergent interventional program, called surf therapy, can enhance physical and mental health indicators. This approach entails structured sessions that combine surfing lessons, nature exposure, mindfulness practices and psychoeducation with other therapeutic actions.
Objective: This study aimed to present and discuss the results obtained in a psychosocial project that combined actions for mental health promotion, using integrative and complementary practices with surfing and training sessions.