Publications by authors named "E Colato"
Background And Objectives: Disentangling brain aging from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific effects. In this study, we investigated whether a disease-specific model might complement the brain-age gap (BAG) by capturing aspects unique to MS.
View Article and Find Full Text PDFBackground: Substantial physical-disability worsening in relapsing-remitting multiple sclerosis (RRMS) occurs outside of clinically recorded relapse. This phenomenon, termed progression independent of relapse activity (PIRA), is yet to be established for cognitive decline.
Methods: Retrospective analysis of RRMS patients.
Article Synopsis
- In multiple sclerosis clinical trials, standard MRI measures often overlook specific regional effects, prompting the need for a more targeted analysis approach.
- Researchers developed a technique using independent component analysis to assess co-varying grey matter volumes in individual MRI scans, allowing for better understanding of treatment and disability progression.
- The study, analyzing data from over 5,000 participants across various MS types, identified 17 distinct patterns of regional volume loss, highlighting faster deterioration in certain networks among secondary progressive MS patients compared to those with relapsing-remitting forms.
Association of Levels of CSF Osteopontin With Cortical Atrophy and Disability in Early Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
September 2024
Background And Objectives: To evaluate CSF inflammatory markers with accumulation of cortical damage as well as disease activity in patients with early relapsing-remitting MS (RRMS).
Methods: CSF levels of osteopontin (OPN) and 66 inflammatory markers were assessed using an immune-assay multiplex technique in 107 patients with RRMS (82 F/25 M, mean age 35.7 ± 11.
Objective: Cognitive and affective symptoms in multiple sclerosis (MS) can be independently impaired and have different pathways of progression. Cognitive alterations have been described since the earliest MS stages; by contrast, the social cognition (SC) domain has never been investigated in the first year from MS diagnosis. We aimed to evaluate SC and unravel its neural bases in newly diagnosed MS patients.
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