INTERCEPT-AD, a phase 1 study of intravenous sabirnetug in participants with mild cognitive impairment or mild dementia due to Alzheimer's disease.

Background: Soluble species of multimeric amyloid-beta including globular amyloid-beta oligomers (AβOs) and linear amyloid-beta protofibrils are toxic to neurons. Sabirnetug (ACU193) is a humanized monoclonal antibody, raised against globular species of soluble AβO, that has over 650-fold greater binding affinity for AβOs over monomers and appears to have relatively little binding to amyloid plaque.

Objectives: To assess safety, pharmacokinetics, and exploratory measures including target engagement, biomarker effects, and clinical efficacy of sabirnetug in participants with early symptomatic Alzheimer's disease (AD; defined as mild cognitive impairment and mild dementia due to AD).

Radiative corrections: from medium to high energy experiments.

Radiative corrections are crucial for modern high-precision physics experiments, and are an area of active research in the experimental and theoretical community. Here we provide an overview of the state of the field of radiative corrections with a focus on several topics: lepton-proton scattering, QED corrections in deep-inelastic scattering, and in radiative light-hadron decays. Particular emphasis is placed on the two-photon exchange, believed to be responsible for the proton form-factor discrepancy, and associated Monte-Carlo codes.

Scleromyxedema and Breast-Implant Associated Lymphoma: Investigating an Unusual Clinical Association.

Scleromyxedema, a rare skin condition, is characterized by a waxy-appearing papular eruption that tends to impact middle-aged adults. Scleromyxedema is often linked to monoclonal gammopathies. However, some patients do not have a coinciding monoclonal gammopathy and experience an atypical presentation of the disease.

Reversible and Ultrasensitive Detection of Nitric Oxide Using a Conductive Two-Dimensional Metal-Organic Framework.

This paper describes the use of a highly crystalline conductive 2D copper(hexaiminobenzene) (Cu(HIB)) as an ultrasensitive (limit of detection of 1.8 part-per-billion), highly selective, reversible, and low power chemiresistive sensor for nitric oxide (NO) at room temperature. The Cu(HIB)-based sensors retain their sensing performance in the presence of humidity, and exhibit strong signal enhancement towards NO over other highly toxic reactive gases, such as NO, HS, SO, NH, CO, as well as CO.