Publications by authors named "E Cinar"
Hirschsprung disease, a congenital disease characterized by the absence of ganglion cells, presents significant surgical challenges. Addressing a critical gap in intraoperative diagnostics, we introduce transformative artificial intelligence approach that significantly enhances the detection of ganglion cells in frozen sections. The data set comprises 366 frozen and 302 formalin-fixed-paraffin-embedded hematoxylin and eosin-stained slides obtained from 164 patients from 3 centers.
View Article and Find Full Text PDFPeriprosthetic joint infection (PJI) is considered a rare but devastating complication after total joint arthroplasty (TJA). The problem lies in the fact that there is a paucity of "gold standard" diagnostic tests that make the diagnosis of PJI extremely challenging. Recently, there have been increasing evidence-based guidelines that have been introduced to standardise the approach to a patient with a suspected PJI.
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- Extracellular aggregation of amyloid-beta (Aβ) in the brain is linked to Alzheimer's disease (AD), and its intraneuronal accumulation may also contribute to disease progression.
- The study investigates the effect of tripeptidyl peptidase-1 (TPP1), a lysosomal enzyme, and its recombinant form (cerliponase alfa) in reducing Aβ levels within neuron cells while examining the role of autophagy.
- Results showed that cerliponase alfa decreased Aβ accumulation and triggered autophagy-related pathways, suggesting TPP1 enhancement might be a potential Alzheimer’s therapy.
Predictive prognostic scoring (PS) systems are not primarily applicable to elderly patients with classical Hodgkin lymphoma (cHL). The objective of this study was to develop a PS system for these patients. The derivation cohort (DC) was utilized for model development, consisting of 97 variables.
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